Bone remodeling is a dynamic process which involves the formation of new bone by osteoclasts and the absorption of old bone by osteoblasts. The balance between these two key processes is necessary to maintain healthy bone structure. We are interested in studying how this balance is maintained by determining how signal transduction cascades are integrated into a biological response, specifically at the level of transcription. Our lab is focused on trying to identify and characterize new proteins that interact with the transcription factor MITF. Different genetic and biochemical approaches are being used including techniques such as cell culture, yeast two hybrid screens, and the expression of recombinant proteins for in-vitro binding assays.